Citrulline Malate Powder 810 grams

Description

Pure Citrulline Malate 2:1 is a mild and slightly tart tasting powder that mixes easily in water, juice, smoothie, etc.

Citrulline increases cellular arginine and can enhance nitric oxide production. Nitric oxide can support healthy cardiovascular function by increasing blood flood and relaxing blood vessels.

Furthermore, citrulline plays a crucial role in the urea cycle, the body’s main method of eliminating toxic ammonia produced as our muscles function. By assisting in this detoxification process, citrulline can support strong healthy muscle mass in active adults and slow muscle loss as we age.

Malic acid is a key part of the Krebs cycle, which is how the body generates energy from food.

Taking citrulline malate can have noticeable effects, especially if you’re using it for exercise or endurance. Since it combines L-citrulline with malic acid, it offers both nitric oxide-boosting and energy-production benefits. Here’s how it might make you feel:

Immediate Effects (Within 30–60 Minutes)

1. Increased Blood Flow & Muscle Pump
   • You might feel your muscles looking and feeling fuller due to improved circulation.
   • Vascularity may increase, especially if you’re lean.
2. Improved Endurance & Reduced Fatigue
   • You may work out longer without feeling as tired.
   • Some users report feeling like they can push through extra reps with less burn.
3. Better Oxygen Utilization & Stamina
   • You might find cardio feels easier due to improved oxygen delivery to muscles.
   • This is especially noticeable for runners, cyclists, and HIIT athletes.
4. Mild Energy Boost (Non-Stimulant)
   • The malate part helps with ATP production (cellular energy), which can give a clean, non-jittery boost.
   • Unlike caffeine, it doesn’t make you feel wired, but you may notice less sluggishness.

After Regular Use (Days to Weeks)

1. Less Muscle Soreness
   • You might wake up less sore after intense workouts.
   • Recovery time between training sessions could improve.
2. More Strength & Power Output
   • Some studies suggest better power generation over time, meaning you may lift heavier weights or sprint harder.
3. Improved Overall Blood Flow & Heart Health
   • Some users report feeling warmer hands and feet, thanks to improved circulation.
   • Over time, it may help with lower blood pressure.

Possible Side Effects

• Digestive issues (higher doses, usually above 10g, may cause bloating or stomach discomfort).
• Lower blood pressure (this is usually good, but if you already have low BP, it could cause dizziness).

How Long Does It Take to Work?

• Pre-workout effects: ~30–60 minutes.
• Endurance & recovery benefits: After a few weeks of consistent use.

Biochemistry of Citrulline Malate and Its Benefits

Citrulline malate is a combination of L-citrulline (a non-essential amino acid) and malate (a key intermediate in the Krebs cycle). Together, they enhance nitric oxide production, ammonia clearance, and ATP synthesis, leading to the performance and recovery benefits.

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1. Nitric Oxide (NO) Synthesis → Increased Blood Flow & Muscle Pump

Pathway: Citrulline → Arginine → Nitric Oxide

• L-citrulline is converted into L-arginine in the kidneys by the enzyme argininosuccinate synthetase.
• L-arginine is then used by nitric oxide synthase (NOS) to produce nitric oxide (NO).
• NO is a vasodilator, meaning it relaxes blood vessels, improving blood flow, oxygen, and nutrient delivery to working muscles.

🚀 Result:

• Increased muscle pump (vascularity and fullness).
• Enhanced oxygen and nutrient transport during exercise.
• Lower perceived exertion due to better oxygen delivery.

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2. Ammonia Clearance → Delayed Fatigue & Faster Recovery

Pathway: Urea Cycle

• Citrulline plays a role in the urea cycle, a metabolic pathway that removes excess ammonia from the body.
• During intense exercise, ammonia accumulates from ATP breakdown and protein metabolism.
• Citrulline helps convert ammonia into urea, which is then excreted in urine.

🛡 Result:

• Delays muscle fatigue by preventing ammonia buildup.
• Reduces post-workout soreness and promotes recovery.
• Enhances endurance, especially in high-rep training and cardio.

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3. Malate & ATP Production → Increased Energy Levels

Pathway: Krebs Cycle (TCA Cycle)

• Malate is an intermediate in the Krebs cycle, which generates ATP (the body’s energy currency).
• It contributes to oxidative phosphorylation, helping produce more ATP per oxygen molecule.
• This means muscles generate energy more efficiently, reducing reliance on anaerobic glycolysis (which produces lactic acid).

⚡ Result:

• Increases energy production without causing a stimulant-like crash.
• Boosts endurance by optimizing aerobic metabolism.
• Reduces lactic acid buildup, delaying muscle burn and fatigue.

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4. Increased Arginine Availability → More Than Direct L-Arginine Supplementation

• Unlike direct L-arginine supplementation (which is broken down by arginase in the liver), citrulline bypasses this and raises plasma arginine levels more effectively.
• This leads to higher NO production and better endurance benefits compared to taking arginine alone.

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5. Improved Muscle Strength & Performance

Mechanisms Involved:

• Better oxygenation → improved muscle contractions.
• More ATP → higher power output.
• Less fatigue → ability to push harder for longer.

💪 Result:

• Increased strength and power over time.
• Faster recovery between sets and workouts.
• Reduced delayed onset muscle soreness (DOMS).

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